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HAX-1 alters cyclophilin-D levels in infected cardiomyocytes. (A and B) Cyclophilin-D levels were reduced when HAX-1 was acutely overexpressed in rat cardiomyocytes. n = 4; *P < 0.05 vs. GFP. (C and D) Cyclophilin-D levels were increased when HAX-1 was acutely down-regulated in rat cardiomyocytes. n = 4; *P < 0.05 vs. GFP. (E and F) Mitochondrial membrane potential was protected with increased HAX-1 expression levels. n = 6; *P < 0.05 vs. GFP.
