Fig. S9.
The number of mutations M and Meq from simulation of different growth models. M is the number of mutations in a population of size NT = 105 grown from (A) the exponential model, (B) the 2D growth model, and (C) the 3D growth model. Meq is the equilibrium number of mutations formulated as θ ln(NT). θ is the mutation parameter that was estimated by randomly sampling 23 cells in the population of NT = 105. The method is Ewens’ sampling formula, using the allele frequency spectrum of the 23 sampled cells. Mutation rate in the coding region was set as u = 0.03 per cell division in all simulations.