Fig. 2.

Summary of in vitro ADAM cleavage of naked peptides and glycopeptides. Peptide sequences covering known ADAM processing sites (arrows and numbers indicate cleavage sites and ADAM isoforms, respectively). ADAM8, -9, -10, -12, and -17 were tested on all peptides that were in vitro O-glycosylated. Numbers in red indicate that we observed protection from cleavage after glycosylation, numbers in black indicate no effect, and numbers in green indicate that cleavage was increased. No cleavage was observed of BTC and TGFR1. *The ADAM17 cleavage of ERBb4 shifted from H⁶⁴²↓STLP↓Q of the naked peptide to ⁶³⁷P↓W of the glycopeptide, and ERBb4 glycosylation increased cleavage by ADAM10.