Fig. S1.

Chemical examples from the published network. Central estradiol and cholesterol molecules were linked when hormone therapies were found to have no effect on reducing heart disease (PMID 10954759 and 12904517). RNA and zinc (PMID 4040853) were recombined in the discovery of “zinc fingers” of amino acids, which are essential for gene regulation and ribosome synthesis. Bromodeoxyuridine, which replaced thymidine in DNA and so “labeled” replicated DNA, allowed scientists to discover cell division in the adult hippocampus (PMID 9809557). HIV therapeutics zidovudine, indinavir, stavidine, and lamivudine were combined in clinical trials of promising antiretroviral mixtures (PMID 9287227). Commercially available protein kinase inhibitors, including KT 5720, rottlerin, quercetin, wortmannin, and the more recently discovered Y 27632, were tested against an array of protein kinases (PMID 10998351).