Fig. 1.

Anti-VEGF treatment improves rotarod performance and decreases Nf2^−/− tumor tissue edema. (A) Rotarod test was carried out in mice bearing size-matched tumors, followed by tumor collection to evaluate edema (B and C). The average time to fall from the rotating cylinder was normalized to the value from each mouse on the first day and presented as relative rotarod endurance. (B) Edema index significantly inversely correlates with rotarod duration. Pearson product moment correlation coefficient r = −0.7416, P = 0.006. (C) B20 treatment, as monotherapy as well as in combination with radiation therapy (5 Gy), significantly decreased tumor edema. Representative of at least three independent experiments (n = 8), data presented are mean ± SEM. *P < 0.01, **P < 0.005.