Fig. 6.

Combination therapy more effectively inhibits growth of Nf2^−/− schwannomas. Kaplan–Meier survival curves (A) and tumor growth curves (B) of mice in Nf2^−/− cranial window model. Tumor growth in control, B20, 5 Gy, and two different combination groups [radiation given 2 d before (combine −2 d) or after (combine 2 d) B20 treatment] were measured by OFDI (n = 8). **, combined (2 d) compared with B20 or radiation only groups. (C) Tumor growth was measured by whole body imaging (WBI, n = 8) in Nf2^−/− sciatic nerve tumor. (D) Tumor growth delay (vs. control) was defined by the time taken for tumors to double their WBI reading. (E) Tumor growth in control, B20, 5 Gy, 10 Gy, and B20 combined with 5 Gy were measured by WBI. Representative of at least three independent experiments, all data presented are mean ± SEM. *P < 0.05, **P < 0.01.