Table 1. Patient characteristics.
| Proton pump inhibitor (n = 623) | H2 receptor antagonist (n = 128) | No acid suppressive medications (n = 438) | P value | |
|---|---|---|---|---|
| Age mean (s.d.), years | 64.5±10.8 | 63.5±11.7 | 62.0±12.6 | 0.003 |
| Male sex, (%) | 426 (68.4) | 89 (70.1) | 318 (72.6) | 0.335 |
| Dialysis vintage mean (s.d.), years | 112.6±96.5 | 100.4±65.6 | 108.8±92.3 | 0.382 |
| Body mass index mean (s.d.) | 22.2 | 22.0 | 22.2 | 0.89 |
| Systolic blood pressure mean (s.d.), mmHg | 151±22 | 157±22 | 152±23 | 0.025 |
| Diastolic blood pressure mean (s.d), mmHg | 79±14 | 84±14 | 79±14 | 0.002 |
| Past medical history (%) | ||||
| Diabetes mellitus | 255 (41.1) | 44 (34.7) | 148 (34.0) | 0.05 |
| Ischemic heart disease | 159 (25.5) | 19 (14.8) | 35 (8.0) | <0.001 |
| Cerebral infarction | 85 (13.6) | 19 (14.8) | 37 (8.5) | 0.02 |
| Gastric hemorrhage | 124 (19.9) | 17 (13.3) | 36 (8.2) | <0.001 |
| Atrial fibrillation | 76 (12.2) | 15 (11.7) | 46 (10.5) | 0.694 |
| Medications (%) | ||||
| Aspirin | 307 (49.3) | 52 (40.6) | 130 (29.7) | <0.001 |
| Cilostazol | 51 (8.2) | 7 (5.8) | 28 (6.4) | 0.387 |
| Clopidogrel | 74 (11.9) | 12 (9.4) | 19 (4.3) | <0.001 |
| Vitamin K antagonist | 61 (9.8) | 11 (8.6) | 25 (5.7) | 0.056 |
| Vitamin D receptor antagonist | 417 (66.9) | 62 (48.4) | 280 (63.9) | <0.001 |
| ACE-I or ARB | 332 (54.5) | 52 (40.9) | 217 (51.4) | 0.02 |
| Furosemide | 148 (23.8) | 29 (22.7) | 114 (26.0) | 0.614 |
| Laboratory measurements | ||||
| Hemoglobin (g/dL) | 10.4±1.0 | 10.6±1.0 | 10.6±1.1 | 0.037 |
| Albumin (g/dL) | 3.7±0.3 | 3.7±0.4 | 3.8±0.3 | 0.054 |
| Blood urea nitrogen (mg/dL) | 63.4±14.4 | 66.03±14.79 | 67.46±13.75 | <0.001 |
| Creatinine (mg/dL) | 11.24±2.87 | 12.38±3.43 | 11.98±3.29 | <0.001 |
| Sodium (mEq/L) | 139.0±3.0 | 138.7±3.0 | 139.2±2.7 | 0.298 |
| Potassium (mEq/L) | 4.98±0.73 | 4.99±0.73 | 5.03±0.68 | 0.559 |
| C-reactive protein (mg/dL) | 0.57±1.39 | 0.49±1.10 | 0.41±1.70 | 0.264 |
| Kt/V | 1.40±0.27 | 1.40±0.25 | 1.38±0.24 | 0.435 |
| Alkaline phosphatase (IU/L) | 252±126 | 222±89 | 232±118 | 0.009 |
| Calcium (mg/dL) | 8.8±0.6 | 9.0±0.6 | 9.0±0.7 | <0.001 |
| Phosphorus (mg/dL) | 5.5±1.4 | 5.7±0.6 | 5.5±1.3 | 0.293 |
| Parathyroid hormone (pg/mL) | 173±127 | 111±181 | 181±166 | 0.009 |
P values reflect group across differences. Abbreviations: H2,histamine 2; ACE-I, angiotensin converting enzyme inhibitor; ARB, angiotensin II receptor blocker. Conversion factors for units: serum creatinine in mg/dL to mol/L, *88.4; blood urea nitrogen in mg/dL to mmol/L,*0.357; Calcium in mg/dL to mmol/L,*0.2495; Phosphorus in mg/dL to mmol/L, *0.3229.