Figure 7.

Effect of disease progression in HSV-2 infected mice. Poly I:C 25 μg suspended in 30 μl Lyovec transfection reagent was delivered to each mice prophylactically (n = 10) or therapeutically (n = 10), 16 h before or 4 h after, intravaginal inoculation of HSV-2 (3000 pfu/mouse). Mice were then monitored daily for genital pathology (A) and survival rate (B). Groups were compared for statistical significance relative to HSV-2 infection group (n = 10) by analysis of variance (*P < 0.05, **P < 0.01).