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. Author manuscript; available in PMC: 2015 Nov 30.
Published in final edited form as: Curr Mol Pharmacol. 2015;8(1):12–21. doi: 10.2174/1874467208666150507103417

Fig. 2. Disruption of the AKAP15-leucine zipper interaction inhibits β-adrenergic receptor regulation of CaV1.2 channels in rat ventricular myocytes.

Fig. 2

(A), Left panel, representative currents elicited by 300-ms test pulses to 0 mV before (closed symbols) and after (open symbols) 5 min exposure to Iso (1 μM). Right panel, mean (± sem) current-voltage relationships before (closed symbols) and after (open symbols) 5 min exposure to isoproterenol in the absence of peptide dialysis. (B), the effect of intracellular dialysis with AKAP15LZ (38–54) (100 μM; n = 14, black triangles) on the response of ICa to isoproterenol as compared to control (circles and gray). Modified from [61].