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. Author manuscript; available in PMC: 2015 Nov 30.
Published in final edited form as: Prog Mol Biol Transl Sci. 2015 Jan 30;131:409–434. doi: 10.1016/bs.pmbts.2014.11.010

Figure 3. AMPK activation pathway.

Figure 3

AMPK activation phosphorylates TSCs at Ser 1227 and 1345 leading to the inhibition of mTORC1. This is shown in the figure as an uncoupling of mTORC1 from Trk signaling via phosphorylation of TSC1/2 by AMPK. AMPK activation also phosphorylates Braf (Raf) at Ser 729 leading to inhibition of ERK signaling. Again, this is shown in the figure by an uncoupling of Raf/Mek signaling to ERK, MNK and eIF4E via phosphorylation of Raf at Ser 729. Finally, AMPK phosphorylates IRS1 at Ser 789 leading to further inhibition of tyrosine kinase receptor signaling.