Skip to main content
. 2015 Nov 30;10(11):e0143908. doi: 10.1371/journal.pone.0143908

Fig 5. Effect of D3 receptor antagonist on preadolescent stress-induced anxiety-related behaviors in adult drd3-EGFP mice.

Fig 5

Adult male drd3-EGFP mice were either not stressed (blue, n = 11) or subjected to repeated restraint stress and social isolation during preadolescence (red, n = 11). Horizontal locomotor activity (A) and number of center zone entries (B) were measured in an Open Field test in adulthood. Significant reduction in locomotor activity and center zone entries were observed in stressed drd3-EGFP mice (*, p<0.05). Administration of 10 mg/kg SB277011-A (green cross hatch; n = 6) but not saline (pink cross hatch, n = 6) to drd3-EGFP mice ten minutes before each restraint stress episode during preadolescence prevented the reduction of locomotor activity (A) and center zone entries observed in adulthood (B) (**, p<0.001 compared to saline-injected stressed mice and +, p<0.05 compared to non-injected stressed mice). Error bars represents ± SEM.