Table 2.

List of adverse effects from all studies (pooled data)²²,²⁴,²⁶,²⁷

	BBFC (n=1,077)	Brinzolamide (n=646)	Brimonidine (n=627)
Ocular hyperemia	36 (3.3%)	4 (0.6%)	8 (1.7%)
Eye pain	27 (2.5%)	11 (1.7%)	5 (0.8%)
Dysgeusia	39 (3.6%)	42 (6.5%)	3 (0.3%)
Blurred vision	41 (3.8%)	31 (4.8%)	4 (0.4%)
Dry mouth	31 (2.8%)	2 (0.3%)	20 (3.2%)
Conjunctivitis	16 (4.8%)	0	8 (1.2%)
Eye pruritus	25 (2.3%)	8 (1.2%)	4 (1.1%)
Allergic conjunctivitis	37 (2.4%)	2 (0.3%)	10 (1.5%)
Eye allergy	22 (2.2%)	0	7 (1.1%)
Eye irritation	30 (2.7%)	10 (1.5%)	13 (2.1%)
Conjunctival hyperemia	17 (1.5%)	8 (1.2%)	9 (1.4%)
Dry eyes	7 (1.1%)	5 (0.8%)	10 (1.6%)

Abbreviation: BBFC, brinzolamide 1% and brimonidine 0.2% fixed combination.