Table 2. Risk of aggressive prostate cancer (Gleason score ≥ 7) by PSA variation over time (after Boniol et al, 2015).

PSA variation	Subjects	Prostate cancers	Gleason score ≥ 7	OR*	95%CI
					Lower bound	Upper bound
< -50%	872	25	16	0.75	0.33	1.71
-50%; -20%	5199	263	149	1.01	0.77	1.32
-20%; +20%	15723	1424	806	1.00	Reference
+20%; +50%	5697	659	371	0.98	0.82	1.19
> +50%	3766	381	214	0.95	0.75	1.19

^*Model adjusted for age and baseline PSA value.