Fig. 1.

A) Venn's diagram showing the overlap between the significantly enriched pathways in Sox4^WT vs Sox4^cKO mouse skin in Telogen (green) and Anagen (yellow). Only pathways showing FDR < 0.05 were included for this comparison. Note that most deregulated pathways belong to the Anagen group, reinforcing a role for Sox4 in this condition, and that the overlap is minimal between both categories.

B) Enrichment plots for selected pathways, obtained from the NCI repository at FDR < 0.150, where N indicates the number of genes included in each list, and FDR means false discovery rate (q value). The red to blue bar represents the ranked list of genes (red = Sox4^WT, blue = Sox4^cKO). Genes showing differential expression between genotypes are located at the edges of the bar, and similarly-expressed genes are in the centre. The Y axis represents the enrichment score (ES). Plk1, ATM, nuclear β-catenin, E2F, FoxM1 and TAP63 pathways are shown from left to right and top to bottom.

C) Comparison of the values obtained by qPCR and microarray in Sox4^WT vs Sox4^cKO mouse skin, for the selected DEGs. Fold change relative to Sox4^WT (set to 1) is shown. N = 6 mice per genotype.