Table 1.
Clinical correlation of miR-431 expression in HCC.
| Clinicopathologic features | Total no. of patients, n = 86 | No. of patients |
P | ||
|---|---|---|---|---|---|
| Low miR-431 | High miR-431 | ||||
| Age (y) | <50 | 36 | 15 | 21 | 0.190 |
| ⩾50 | 50 | 28 | 22 | ||
| Sex | Male | 65 | 34 | 31 | 0.451 |
| Female | 21 | 9 | 12 | ||
| HBV | Absent | 28 | 12 | 16 | 0.357 |
| Present | 58 | 31 | 27 | ||
| Serum AFP level (ng/mL) | <400 | 32 | 14 | 18 | 0.372 |
| ⩾400 | 54 | 29 | 25 | ||
| Tumor size (cm) | <5 | 32 | 13 | 19 | 0.181 |
| ⩾5 | 54 | 30 | 24 | ||
| No. of tumor nodules | 1 | 68 | 31 | 37 | 0.112 |
| ⩾2 | 18 | 12 | 6 | ||
| Cirrhosis | Absent | 36 | 15 | 21 | 0.190 |
| Present | 50 | 28 | 22 | ||
| Venous infiltration | Absent | 76 | 35 | 41 | 0.044⁎ |
| Present | 10 | 8 | 2 | ||
| Edmondson–Steiner grading | I + II | 65 | 27 | 38 | 0.006⁎ |
| III + IV | 21 | 16 | 5 | ||
| TNM tumor stage | I + II | 66 | 28 | 38 | 0.011⁎ |
| III + IV | 20 | 15 | 5 | ||
HCC, hepatocellular carcinoma; HBV, hepatitis B virus; AFP, alpha-fetoprotein; TNM, tumor-node-metastasis.
⁎
Statistically significant.