Table 1.
Top 64 most enriched pathways in the C4KD cells compared to the control cells.
The top pathways were selected with the number of hits ≥ 20 and the p-value < 0.15.
| Hits | Size | % | p-value | Kegg id | Name of pathway |
|---|---|---|---|---|---|
| 330 | 1271 | 26 | 1.3e-11 | 01100 | Metabolic pathways |
| 127 | 397 | 32 | 6.4e-11 | 05200 | Pathways in cancer |
| 95 | 352 | 27 | 5.3-e05 | 04151 | PI3K-Akt signaling pathway |
| 74 | 232 | 32 | 6.3e-07 | 05203 | Viral carcinogenesis |
| 73 | 206 | 35 | 6.1e-09 | 05205 | Proteoglycans in cancer |
| 71 | 276 | 26 | 1.8e-03 | 05206 | MicroRNAs in cancer |
| 68 | 254 | 27 | 7.2e-04 | 04010 | MAPK signaling pathway |
| 66 | 208 | 32 | 3.0e-06 | 04510 | Focal adhesion |
| 64 | 170 | 38 | 3.4e-09 | 03013 | RNA transport |
| 64 | 218 | 29 | 6.3e-05 | 01130 | Biosynthesis of antibiotics |
| 64 | 235 | 27 | 6.3e-04 | 04144 | Endocytosis |
| 60 | 145 | 41 | 1.1e-10 | 03010 | Ribosome |
| 58 | 230 | 25 | 6.9e-03 | 04014 | Ras signaling pathway |
| 54 | 214 | 25 | 8.7e-03 | 04015 | Rap1 signaling pathway |
| 50 | 133 | 38 | 1.8e-07 | 03040 | Spliceosome |
| 49 | 118 | 42 | 5.5e-09 | 04919 | Thyroid hormone signaling pathway |
| 48 | 177 | 27 | 3.0e-03 | 05202 | Transcriptional misregulation in cancer |
| 45 | 168 | 27 | 5.1e-03 | 04141 | Protein processing in endoplasmic reticulum |
| 45 | 172 | 26 | 8.1e-03 | 04022 | cGMP-PKG signaling pathway |
| 45 | 179 | 25 | 1.7e-02 | 00230 | Purine metabolism |
| 44 | 198 | 22 | 1.1e-01 | 04062 | Chemokine signaling pathway |
| 43 | 139 | 31 | 2.7e-04 | 00190 | Oxidative phosphorylation |
| 43 | 143 | 30 | 5.4e-04 | 04120 | Ubiquitin mediated proteolysis |
| 41 | 142 | 29 | 1.7e-03 | 04910 | Insulin signaling pathway |
| 41 | 129 | 32 | 2.0e-04 | 04152 | AMPK signaling pathway |
| 41 | 174 | 24 | 5.5e-02 | 04145 | Phagosome |
| 40 | 181 | 22 | 1.3e-01 | 04020 | Calcium signaling pathway |
| 40 | 143 | 28 | 3.6e-03 | 04310 | Wnt signaling pathway |
| 39 | 159 | 25 | 3.5e-02 | 04921 | Oxytocin signaling pathway |
| 39 | 125 | 31 | 4.3e-04 | 04110 | Cell cycle |
| 38 | 154 | 25 | 3.4e-02 | 04390 | Hippo signaling pathway |
| 37 | 104 | 36 | 2.8e-05 | 00240 | Pyrimidine metabolism |
| 37 | 124 | 30 | 1.5e-03 | 04142 | Lysosome |
| 37 | 103 | 36 | 2.2e-05 | 04922 | Glucagon signaling pathway |
| 36 | 134 | 27 | 1.1e-02 | 04068 | FoxO signaling pathway |
| 35 | 122 | 29 | 4.0e-03 | 04722 | Neurotrophin signaling pathway |
| 35 | 115 | 30 | 1.3e-03 | 04114 | Oocyte meiosis |
| 34 | 140 | 24 | 5.2e-02 | 04530 | Tight junction |
| 33 | 140 | 24 | 7.8e-02 | 04550 | Signaling pathways regulating pluripotency of stem cells |
| 31 | 94 | 33 | 5.6e-04 | 00564 | Glycerophospholipid metabolism |
| 30 | 109 | 28 | 1.3e-02 | 04066 | HIF-1 signaling pathway |
| 29 | 101 | 29 | 8.1e-03 | 05231 | Choline metabolism in cancer29 |
| 29 | 117 | 25 | 5.5e-02 | 01200 | Carbon metabolism |
| 28 | 124 | 23 | 1.5e-01 | 04071 | Sphingolipid signaling pathway |
| 27 | 87 | 31 | 3.3e-03 | 04540 | Gap junction |
| 26 | 88 | 30 | 7.9e-03 | 04512 | ECM-receptor interaction |
| 26 | 96 | 27 | 2.5e-02 | 03015 | mRNA surveillance pathway |
| 25 | 83 | 30 | 7.0e-03 | 03008 | Ribosome biogenesis in eukaryotes |
| 25 | 99 | 25 | 5.9e-02 | 04915 | Estrogen signaling pathway |
| 25 | 67 | 37 | 2.3e-04 | 04115 | p53 signaling pathway |
| 25 | 89 | 28 | 1.8e-02 | 04912 | GnRH signaling pathway |
| 25 | 82 | 30 | 5.9e-03 | 04210 | Apoptosis |
| 25 | 72 | 35 | 8.0e-04 | 04920 | Adipocytokine signaling pathway |
| 23 | 74 | 31 | 6.3e-03 | 04520 | Adherens junction |
| 23 | 87 | 26 | 4.3e-02 | 04012 | ErbB signaling pathway |
| 23 | 83 | 28 | 2.6e-02 | 03018 | RNA degradation |
| 23 | 82 | 28 | 2.2e-02 | 003320 | PPAR signaling pathway |
| 22 | 74 | 30 | 1.3e-02 | 04917 | Prolactin signaling pathway |
| 22 | 82 | 27 | 4.0e-02 | 04070 | Phosphatidylinositol signaling system |
| 22 | 66 | 33 | 2.9e-03 | 05230 | Central carbon metabolism in cancer |
| 21 | 82 | 26 | 6.9e-02 | 04350 | TGF-beta signaling pathwa |
| 20 | 79 | 25 | 8.2e-02 | 01230 | Biosynthesis of amino acids |
| 20 | 66 | 30 | 1.4e-02 | 00010 | Glycolysis / Gluconeogenesis |
| 20 | 61 | 33 | 5.4e-03 | 04150 | mTOR signaling pathway |