Table 3.
Patients characteristics, clinicopathologic features, and IHC analysis: association with OS. Results from Kaplan-Meier univariate and Cox multiple regression analyses.
| Covariates | N | 5-year survival | Kaplan-Meier | Cox regressiond | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Deaths | SP∗ | |||||||||
| n | % | % | HR | 95% CI | p valueb | HR | 95% CI | p valuee | ||
| Gender | 0.967 | 0.611 | ||||||||
| Female | 20 | 9 | 45.0 | 54.6 | 1 | 1 | ||||
| Male | 62 | 28 | 45.2 | 54.2 | 1.12 | 0.51–2.47 | 1.28 | 0.50–3.30 | ||
| Age at diagnosis | 0.850 | 0.619 | ||||||||
| ≤70 years | 46 | 20 | 43.5 | 56.5 | 1 | 1 | ||||
| >70 years | 36 | 17 | 47.2 | 50.6 | 1.06 | 0.55–2.03 | 1.22 | 0.56–2.66 | ||
| Smoking habit | 0.066 | 0.091 | ||||||||
| Ex/never-smoker | 28 | 9 | 32.1 | 67.2 | 1 | 1 | ||||
| Current smoker | 54 | 28 | 51.9 | 47.7 | 1.99 | 0.94–4.24 | 1.98 | 0.90–4.39 | ||
| Pathological TNM | <0.001c | <0.001 | ||||||||
| Stage I | 44 | 12 | 27.3 | 71.9 | 1 | 1 | ||||
| Stage II | 15 | 9 | 60.0 | 40.0 | 2.81 | 1.18–6.69 | 3.51 | 1.35–9.07 | ||
| Stage III | 23 | 16 | 69.7 | 30.4 | 4.44 | 2.08–9.46 | 6.54 | 2.86–14.93 | ||
| Histological type | 0.998 | 0.857 | ||||||||
| Nonsquamous | 54 | 25 | 46.3 | 52.9 | 1 | — | 1 | |||
| Squamous | 28 | 12 | 42.9 | 56.9 | 0.97 | 0.49–1.93 | 0.92 | 0.37–2.31 | ||
| ERCC1 | 0.126 | 0.059 | ||||||||
| ≤140 | 33 | 12 | 26.4 | 61.4 | 1 | 1 | ||||
| >140 | 49 | 25 | 51.0 | 47.5 | 1.70 | 0.85–3.39 | 2.08 | 0.97–4.44 | ||
| BRCA1a | 0.308 | 0.750 | ||||||||
| Negative | 36 | 14 | 40.9 | 60.8 | 1 | 1 | ||||
| Positive | 45 | 22 | 60.0 | 46.7 | 1.42 | 0.72–2.77 | 1.14 | 0.51–2.54 | ||
| TSa | 0.242 | 0.023 | ||||||||
| Negative | 66 | 27 | 40.9 | 58.8 | 1 | 1 | ||||
| Positive | 15 | 9 | 60.0 | 40.0 | 1.56 | 0.74–3.32 | 2.93 | 1.16–7.42 | ||
| p53R2a | 0.297 | 0.699 | ||||||||
| Negative | 57 | 27 | 47.4 | 52.1 | 1 | 1 | ||||
| Positive | 24 | 9 | 37.5 | 61.9 | 0.67 | 0.32–1.43 | 0.70 | 0.27–1.83 | ||
| TUBB3 (median H-score) | 0.152 | 0.354 | ||||||||
| ≤60 | 42 | 22 | 52.4 | 46.8 | 1 | 1 | ||||
| >60 | 40 | 15 | 37.5 | 62.3 | 0.62 | 0.32–1.19 | 0.68 | 0.30–1.55 | ||
| RRM1a (median H-score) | 0.832 | 0.624 | ||||||||
| ≤120 | 43 | 19 | 44.2 | 54.7 | 1 | 1 | ||||
| >120 | 38 | 17 | 44.7 | 55.3 | 1.07 | 0.56–2.07 | 0.82 | 0.36–1.84 | ||
| RRM2 (median H-score) | 0.069 | 0.031 | ||||||||
| ≤140a | 42 | 16 | 35.7 | 61.9 | 1 | 1 | ||||
| >140 | 39 | 21 | 53.8 | 45.9 | 1.84 | 0.95–3.56 | 2.26 | 1.08–4.74 | ||
∗SP = cumulative probability of surviving, aexpression level missing for 1 subject, blog-rank (Mantel-Cox) test, ctest for trend, dCox regression analysis performed on 81 subjects with complete data: HR and 95% CI estimated from the final regression model for covariates retained in the model and from the full model for variables removed, and elikelihood ratio test p value.