Table 6.
Results from the DCC NSCLC microarray subset analyses.
| Covariates | N | 5-year survival | Kaplan-Meier | Cox regressionc | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Deaths | SP∗ | |||||||||
| n | % | % | HR | 95% CI | p valuea | HRc | 95% CI | p valued | ||
| Gender | 0.036 | 0.199 | ||||||||
| Males | 174 | 74 | 52.7 | 55.1 | 1 | 1 | ||||
| Females | 156 | 47 | 47.3 | 66.8 | 0.68 | 0.47–0.98 | 1.25 | 0.87–1.80 | ||
| Age at diagnosis | 330 | 121 | 36.7 | 0.43 | 1.03 | 1.01–1.04 | 0.008 | 1.03 | 1.01–1.05 | 0.003 |
| Smoking habits | 0.224 | 0.747 | ||||||||
| Ex/never-smoker | 216 | 71 | 65.5 | 63.9 | 1 | 1 | ||||
| Current smoker | 25 | 10 | 7.6 | 56.2 | 1.32 | 0.68–2.57 | 0.86 | 0.56–1.33 | ||
| Unknown | 89 | 40 | 26.9 | 53.6 | 1.39 | 0.94–2.05 | 1.09 | 0.53–2.26 | ||
| Pathological TNM | 0.000b | 0.000 | ||||||||
| Stage I | 232 | 60 | 25.9 | 71.2 | 1 | 1 | ||||
| Stage II | 84 | 49 | 58.3 | 39.4 | 3.19 | 2.19–4.66 | 3.32 | 2.15–4.62 | ||
| Stage III | 14 | 12 | 85.7 | 0.00 | 6.45 | 3.43–12.15 | 5.39 | 2.84–10.23 | ||
| ERCC1 (median mRNA expression level) | 0.241 | 0.525 | ||||||||
| ≤−0.045 | 181 | 68 | 37.6 | 0.60 | 1 | 1 | ||||
| >−0.045 | 149 | 53 | 35.6 | 0.61 | 0.96 | 0.67–1.37 | 1.39 | 0.96–2.04 | ||
| BRCA1 (median mRNA expression level) | 0.010 | 0.614 | ||||||||
| ≤0.048 | 137 | 40 | 29.2 | 0.68 | 1 | 1 | ||||
| >0.048 | 193 | 81 | 46.7 | 0.53 | 1.64 | 1.12–2.39 | 0.95 | 0.58–1.56 | ||
| TS (median mRNA expression level) | 0.003 | 0.017 | ||||||||
| ≤−0.018 | 166 | 48 | 38.1 | 0.67 | 1 | 1 | ||||
| >−0.018 | 164 | 73 | 44.5 | 0.59 | 1.78 | 1.24–2.56 | 1.57 | 1.08–2.28 | ||
| TUBB3 (median mRNA expression level) | 0.395 | 0.890 | ||||||||
| ≤−0.116 | 189 | 63 | 33.3 | 0.63 | 1 | 1 | ||||
| >−0.116 | 141 | 58 | 41.1 | 0.57 | 1.17 | 0.82–1.67 | 1.21 | 0.82–1.78 | ||
| RRM1 (median mRNA expression level) | 0.130 | 0.419 | ||||||||
| ≤−0.130 | 194 | 65 | 33.5 | 0.63 | 1 | 1 | ||||
| >−0.130 | 136 | 56 | 41.2 | 0.57 | 1.32 | 0.92–1.89 | 0.88 | 0.59–1.32 | ||
| RRM2 (median mRNA expression level) | 0.005 | 0.757 | ||||||||
| ≤0.213 | 155 | 46 | 29.7 | 0.67 | 1 | 1 | ||||
| >0.213 | 175 | 75 | 42.9 | 0.55 | 1.69 | 1.17–2.44 | 1.06 | 0.59–1.88 | ||
∗SP = cumulative probability of surviving, alog-rank (Mantel-Cox) test, btest for trend, cHR and 95% CI from the final regression model for covariates retained in the model and from the full model for variables removed, and dlikelihood ratio test p value.