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. 2015 Dec;146(6):541–546. doi: 10.1085/jgp.20121093510232015c

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© 2015 Groome and Winston

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Figure 10. — Biophysical characterization of INC mutations. (A) Sodium currents in response to command depolarization to voltages from −90 to 60 mV. Effects of INC mutations are shown for activation (B), steady-state fast inactivation (C), entry into fast inactivation (D and E), and recovery (F and G). Legends identify residues and locus by domain and segment. Values represent mean ± SEM (error bars) from 10–23 experiments. The additional panel (H) is shown for g-V relations for hNa_V1.4 and mutations of the INC in domains I and II. Boltzmann fits to each plot are shown by dotted lines.