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. 2015 Dec;146(6):509–525. doi: 10.1085/jgp.201511476

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© 2015 Ammar et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — HyperKPP soleus and EDL but not diaphragm generated less tetanic force than wild-type muscles. (A–C) Tetanic force was elicited with a 200-msec train of 0.3 msec, 10-V square pulses at 140 Hz for the soleus and 200 Hz for the EDL and diaphragm. Data were acquired immediately after adjusting the length for maximum force at the beginning of an experiment. The tetanic forces from every experiment including those for EM measurements were used to calculate mean tetanic force. Error bars represent the SEM of 24 solei, 34 EDL, and 44 diaphragms. *, mean tetanic force of HyperKPP muscles was significantly different from that of wild type; ANOVA and LSD; P < 0.05.