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. 2015 Dec;146(6):509–525. doi: 10.1085/jgp.201511476

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© 2015 Ammar et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 11. — ORM-10103 caused small decreases in tetanic force in the wild-type diaphragm and in the HyperKPP EDL and diaphragm, but not in wild type EDL. (A–D) Muscles were first exposed to 3 µM ORM-10103, an NCX inhibitor, while being exposed to 4.7 mM K⁺. The increase in [K⁺]_e was to 12.5 mM for all muscles, except for the HyperKPP EDL, for which the increase was to 11 mM K⁺, as this muscle was more sensitive to the K⁺-induced force depression. Error bars represent the SEM of 5 muscles. *, mean tetanic force of ORM-10103–exposed muscles was significantly less than the mean value of control; ANOVA and LSD; P < 0.05.