TABLE 2.
Enzymes related to the virulence in Cryptococcus neoformans
| Enzyme | Comment(s) | Reference(s) |
|---|---|---|
| Acid phosphatase | Deficient strains show affected virulence in mouse and Galleria mellonella models of infection | 106 |
| DNase | Acts in degrading host DNA and supplies C. neoformans with nucleotides | 79 |
| Glucosylceramide synthase | Required for virulence in murine model of infection | 127, 128 |
| Laccase | Deficient strains show decreased virulence in survival studies with rabbit and mouse models of infection | 59 |
| Mannosyltransferase | Required for virulence in murine model of infection | 185 |
| Metalloprotease | Deficient strains unable to cross endothelium in in vitro model of human blood-brain barrier and is required for invasion of central nervous system | 113 |
| Phospholipase B | Required in invasion of host tissue and dissemination in murine model | 95 |
| Phospholipase C | Shown to be important for several virulence phenotypes | 101, 102 |
| Superoxide dismutase | Attenuated growth of deficient strains within macrophages | 89 |
| Urease | Deficient strains less virulent than wild-type strain in mouse model of infection and is involved in fungal escape from lung to cross blood-brain barrier | 76 |
| Xylosylphosphotransferase | Deficient strains manifest reduced growth in lung tissue in mouse model of infection | 30 |