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. 2015 Dec 1;5:17288. doi: 10.1038/srep17288

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(a) A general chemical structure of ivermectin, abamectin and doramectin. (b–d) Left:The structure of FXR bound with ivermectin and the docking structures of the FXR docked with abamectin and doramectin in ribbon representation. Right: Schematic representation of interactions between FXR and avermectin analogues. Hydrogen bonds are indicated by arrows from proton donors to acceptors. The helix 3 of the FXR LBD is highlighted in green, the NCoR-2 motif is in brownish red.