Table 2. Association statistics for the known CRC SNPs tested in EC, and vice versa.
| Cancer GWAS | SNP | Chr | Position (build 37) | Nearby gene(s) | Minor Allele | MAF | P-value in other phenotype | OR (minor allele) | L95 CI | U95 CI | Same effect direction in CRC and EC? | iCOGS EC samples included? | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CRC | rs1801133 | 1 | 11,856,378 | MTHFR | A | 0.34 | 0.686 | 0.99 | 0.92 | 1.06 | Yes | No | Hubner et al. Int Journal Cancer2006 |
| CRC | rs10911251 | 1 | 183,081,194 | LAMC1 | C | 0.43 | 0.236 | 1.04 | 0.97 | 1.12 | No | No | Peters et al. Gastroenterology 2013, Whiffin et al. Hum Mol Genet 2014 |
| CRC | rs6691170 | 1 | 222,045,446 | DUSP10 | T | 0.37 | 0.023 | 1.09 | 1.01 | 1.17 | Yes | No | Houlston et al. Nat Gen 2010 |
| CRC | rs10936599 | 3 | 169,492,101 | TERC | T | 0.24 | 0.033 | 0.92 | 0.84 | 0.99 | Yes | No | Houlston et al. Nat Gen 2010 |
| CRC | rs2736100 | 5 | 1,286,516 | TERT | A | 0.5 | 0.000167 | 0.93 | 0.89 | 0.96 | No | Yes | Kinnersley Br J Cancer 2012, Rafnar et al. Nat Gen 2009 Peters et al. Human Genetics 2012 |
| CRC | rs647161 | 5 | 134,499,092 | PITX1 | C | 0.33 | 0.559 | 1.02 | 0.95 | 1.1 | No | No | Jia et al. Nat Gen 2013, Whiffin et al. Hum Mol Genet 2014 |
| CRC | rs1321311 | 6 | 36,622,900 | CDKN1A | A | 0.24 | 0.925 | 1.00 | 0.92 | 1.08 | No | No | Dunlop et al. Nat Gen 2012 |
| CRC | rs16892766 | 8 | 117,630,683 | EIF3H | C | 0.09 | 0.134 | 0.95 | 0.88 | 1.02 | No | Yes | Tomlinson et al. Nat Gen 2008 |
| CRC | rs6983267 | 8 | 128,413,305 | MYC | T | 0.46 | 0.143 | 1.03 | 0.99 | 1.07 | No | Yes | Tomlinson et al. Nat Gen 2007 |
| CRC | rs10795668 | 10 | 8,701,219 | GATA3 | A | 0.32 | 0.715 | 0.99 | 0.92 | 1.06 | Yes | No | Tomlinson et al. Nat Gen 2008 |
| CRC | rs1035209 | 10 | 101,345,366 | NKX2-3, SLC25A28 | T | 0.2 | 0.243 | 1.05 | 0.97 | 1.15 | Yes | No | Whiffin et al. Hum Mol Genet 2014 |
| CRC | rs3824999 | 11 | 74,345,550 | POLD3 | T | 0.49 | 0.647 | 0.98 | 0.92 | 1.05 | Yes | No | Dunlop et al. Nat Gen 2012 |
| CRC | rs3802842 | 11 | 111,171,709 | COLCA1, COLCA2, POU2AF1 | C | 0.31 | 0.513 | 0.99 | 0.94 | 1.03 | No | Yes | Tenesa et al. Nat Gen 2008 |
| CRC | rs10774214 | 12 | 4,368,352 | CCND2 | T | 0.38 | 0.171 | 1.05 | 0.98 | 1.13 | Yes | Yes | Jia et al. Nat Gen 2013, Whiffin et al. Hum Mol Genet 2014 |
| CRC | rs3217810 | 12 | 4,388,271 | CCND2 | T | 0.14 | 0.762 | 1.02 | 0.92 | 1.13 | Yes | No | Peters et al. Gastroenterology 2013, Whiffin et al. Hum Mol Genet 2014 |
| CRC | rs11169552 | 12 | 51,155,663 | DIP2B, ATF1 | T | 0.26 | 0.963 | 1.00 | 0.93 | 1.08 | No | No | Houlston et al. Nat Gen 2010 |
| CRC | rs4444235 | 14 | 54,410,919 | BMP4 | C | 0.48 | 0.1 | 1.03 | 0.99 | 1.07 | Yes | Yes | Houlston et al. Nat Gen 2008 |
| CRC | rs1957636 | 14 | 54,560,018 | BMP4 | T | 0.41 | 0.961 | 1.00 | 0.96 | 1.04 | No | Yes | Tomlinson et al. PLoS Genetics 2011 |
| CRC | rs16969681 | 15 | 32,993,111 | GREM1 | T | 0.09 | 0.379 | 0.97 | 0.90 | 1.04 | No | Yes | Tomlinson et al. PLoS Genetics 2011 |
| CRC | rs11632715 | 15 | 33,004,247 | GREM1 | A | 0.48 | 0.332 | 1.04 | 0.97 | 1.11 | Yes | No | Tomlinson et al. PLoS Genetics 2011 |
| CRC | rs9929218 | 16 | 68,820,946 | CDH1, CDH3 | A | 0.29 | 0.679 | 0.98 | 0.91 | 1.06 | Yes | No | Houlston et al. Nat Gen 2008 |
| CRC | rs4939827 | 18 | 46,453,463 | SMAD7 | C | 0.46 | 0.229 | 0.98 | 0.94 | 1.02 | Yes | Yes | Broderick et al. Nat Gen 2007 |
| CRC | rs10411210 | 19 | 33,532,300 | RHPN2 | T | 0.09 | 0.202 | 1.04 | 0.98 | 1.12 | No | Yes | Houlston et al. Nat Gen 2008 |
| CRC | rs961253 | 20 | 6,404,281 | BMP2 | A | 0.37 | 0.975 | 1.00 | 0.96 | 1.04 | No | Yes | Houlston et al. Nat Gen 2008 |
| CRC | rs4813802 | 20 | 6,699,595 | BMP2 | G | 0.37 | 0.268 | 1.04 | 0.97 | 1.12 | Yes | No | Tomlinson et al. PLoS Genetics 2011 |
| CRC | rs2423279 | 20 | 7,812,350 | HAO1 | C | 0.24 | 0.897 | 1.01 | 0.93 | 1.09 | Yes | No | Jia et al. Nat Gen 2013, Whiffin et al. Hum Mol Genet 2014 |
| CRC | rs4925386 | 20 | 60,921,044 | LAMA5 | T | 0.3 | 0.064 | 1.07 | 1.00 | 1.16 | No | No | Houlston et al. Nat Gen 2010, Peters et al. Human Genetics 2012 |
| EC | rs749292* | 15 | 51,558,731 | CYP19A1 | A | 0.46 | 0.066 | 0.95 | 0.91 | 1.00 | No | Yes | Spurdle et al. Nat Gen 2011 |
| EC | rs4430796* | 17 | 36,098,040 | HNF1B | G | 0.47 | 0.601 | 0.99 | 0.94 | 1.04 | Yes | Yes | Setiawan et al. Cancer Epidemiol Biomarkers Prev 2009 |
Chr = chromosome, OR = odds ratio, MAF = minor allele frequency, OR = odds ratio, L95 CI = lower 95% confidence interval odds ratio, U95 CI = upper 95% confidence interval odds ratio. The original studies providing the data are listed in Supplementary Information.