Table A1:
Indications and Contraindications for Islet Transplantation in the Original Edmonton Protocol
| Indications | Contraindications |
|---|---|
| Age between 18–65 y | Children (< 18 y), elderly (> 65 y) |
| Type 1 diabetes mellitus > 5 y | Obesity and insulin resistance: patients with high body weight (> 90 kg), obesity (BMI > 28 kg/m2 or BMI > 30 kg/m2), or with high insulin requirements (> 1 U/kg/d) |
| Undetected stimulated C-peptide (< 0.48 ng/mL) | Blood HbA1c level > 12% |
| Severe hypoglycemia | Severe kidney dysfunction (creatinine > 200 µmol/L or other parameters) |
| Hypoglycemia unawareness | Infection, neoplasia |
| Glycemic lability (brittle diabetes, high variability in glucose levels despite exogenous insulin therapy) | Psychiatric disease, cognitive impairment, non-compliance |
| Smoking, alcohol use, drug use | |
| Taking systemic steroids | |
| Young women who wish to become pregnant |
Abbreviations: BMI, body mass index; HbA1c, glycosylated hemoglobin.
Source: Data from Shapiro et al, 2000. (7)