Table 2. CAFs with significant or borderline prognostic values in protein microarray profiling.
| Biomarkers | Progression-Free Survivalb |
Overall Survivalb |
Overall Response Rateb |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Median, mos | HR (95% CI) | P | Median, mos | HR (95% CI) | P | ORR (%) | OR (95% CI) | P | |
| Activin-A | |||||||||
| Low vs Higha | 6.8 vs 10.6 | 0.47 (0.27–0.82) | 0.007 | 21.1 v 31.7 | 0.54 (0.26–1.12) | 0.098 | 41.9 vs 48.4 | 1.30 (0.48–3.54) | 0.610 |
| Each SD change | — | 1.09 (0.77–1.53) | 0.637 | — | 0.74 (0.32–1.69) | 0.473 | — | 0.40 (0.07–2.19) | 0.293 |
| ANGPTL4 | |||||||||
| Low vs Higha | 10.5 vs 6.2 | 1.64 (0.97–2.79) | 0.061 | 32.0 vs 24.6 | 2.45 (1.07–5.61) | 0.034 | 67.2 vs 26.1 | 0.16 (0.05–0.55) | 0.004 |
| Each SD change | — | 1.24 (0.95–1.63) | 0.096 | — | 1.73 (1.22–2.49) | 0.002 | — | 0.13 (0.03–0.66) | 0.014 |
| Ang-2 | |||||||||
| Low vs Higha | 10.6 vs 7.1 | 1.24 (0.73–2.10) | 0.430 | 27.5 vs 20.7 | 1.88 (0.92–3.82) | 0.189 | 56.4 vs 34.8 | 0.30 (0.11–0.86) | 0.025 |
| Each SD change | — | 1.12 (0.84–1.49) | 0.439 | — | 1.40 (0.95–2.07) | 0.089 | — | 0.38 (0.13–1.17) | 0.092 |
| GRO | |||||||||
| Low vs Higha | 10.1 vs 7.1 | 1.64 (0.97- 2.75) | 0.077 | 27.5 vs 18.3 | 1.70 (0.85–3.40) | 0.134 | 58.1 vs 32.3 | 0.54 (0.32–1.17) | 0.073 |
| Each SD change | — | 1.02 (0.82–1.28) | 0.835 | — | 0.85 (0.55–1.34) | 0.490 | — | 1.13 (0.68–1.86) | 0.636 |
| HGF | |||||||||
| Low vs Higha | 12.1 vs 5.7 | 1.84 (1.05- 3.24) | 0.034 | 32.7 vs 19.0 | 2.62 (1.09–5.68) | 0.017 | 61.5 vs 28.6 | 0.25 (0.08–0.78) | 0.017 |
| Each SD change | — | 1.18 (0.96–1.44) | 0.091 | — | 1.34(1.01–1.80) | 0.047 | — | 0.28 (0.10–0.82) | 0.020 |
| VEGF-A121 | |||||||||
| Low vs Higha | 10.6 vs 6.1 | 1.85 (1.11–3.08) | 0.019 | 25.2 vs 20.7 | 1.46 (0.73–2.91) | 0.278 | 64.3 vs 35.7 | 0.34 (0.12–0.97) | 0.044 |
| Each SD change | — | 1.50 (1.16–1.94) | 0.002 | — | 1.17 (0.85–1.59) | 0.337 | — | 0.49 (0.18–1.30) | 0.152 |
aPatients were dichotomized according to the median mean densitometric value (MDV) of each molecule. High indicates above the median MDV; low indicates less than or equal to the MDV.
bCox regression analysis was performed to test different clinical outcomes between the lower and upper median MDV or between each standard deviation (SD) increase in MDV. Abbreviations: ORR, overall response rate; ANGPTL4, angiopoietin-like 4; HGF, hepatocyte growth factor; Ang-2, angiopoietin-2; VEGF-A121, isoform vascular endothelial growth factor-A 121. OR, odds ratio; 95% CI, 95% confidence interval. Statistical significance was set at 0.10 based on a two-sided test. Other footnotes as in Table 1.