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. 2015 Dec 1;5:17401. doi: 10.1038/srep17401

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Copyright © 2015, Macmillan Publishers Limited

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(a) Immunoblot of Akt (Ser473), Erk (Thr202/Tyr204), and S6K (Thr389) in L1210 cells within 10 minutes after the depletion of leucine, glutamine, or glucose. (b) Immunoblot of phosphorylation of the downstream target of AMPK, ACC (Ser79), as well as eiF2α (Ser51), PKA (Thr197), and MST1 (Thr183) in L1210 cells within 30 minutes after the depletion of glucose or glutamine. The schematic shows the time of depletion and subsequent fixation of cells. (c) AMPK is not necessary for the growth response upon glucose depletion. AICAR induces MAR reduction through phosphorylation of AMPK, Compound-C successfully inhibits AMPK activity as indicated by the abolishment of MAR reduction, but Compound-C does not abolish MAR reduction in the case of glucose depletion. p-values were calculated by using Welch’s t-test.