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. 2015 Dec;5(12):a021451. doi: 10.1101/cshperspect.a021451

Figure 2.

Figure 2.

Strategies for therapeutic vaccination and/or immunomodulation in patients with chronic hepatitis B (CHB). Option 1: Combination of antiviral treatment nucleos(t)ide and prime–boost vaccination. Option 2: Combination of antiviral treatment nucleos(t)ide and anti-programmed death-ligand 1 (PD-L1). Option 3: Triple therapy with antiviral treatment nucleos(t)ide and prime–boost vaccination and anti-PD-L1. HBcAg, Hepatitis B core antigen; MVA, modified vaccinia Ankara; HBsAg, hepatitis B surface antigen; MVA, modified vaccinia Ankara; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; HBeAG, hepatitis B e antigen; ALT, alanine aminotransferase; IFN, interferon.