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. 2015 Oct 22;137(46):14626–14639. doi: 10.1021/jacs.5b06728

Table 2. EC50 Values for LasR Activation by Library Members in P. aeruginosa PAO-JP2 (plasI-LVAgfp)a.

compound EC50 (μM) 95% CI (μM) max. activation (%)b
1 (OdDHL) 0.139 0.116–0.167 100
2 >200 – 75
8 >200 – 45
9 140 90–210 65
11 2.6 1.9–3.7 80
14 17 11–26 45
15 >200 – 15
16 4.2 2.5–7.3 90
19 0.071 0.044–0.11 100
a

Determined by testing AHLs over a range of concentrations for ability to mediate LasR expression of lasI-LVAgfp.

b

Denotes the highest value of LasR activation seen for each compound at any concentration within the dose–response assay. For the full agonism trace, see Figure S2.