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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Nano Today. 2015 Aug 1;10(4):511–531. doi: 10.1016/j.nantod.2015.06.007

Figure 10.

Figure 10

Carbon nanotube-polymer composite (CNP) for ex vivo T cell expansion. (a) Schematic of CNP assembly. Neutravidin-adsorbed CNTs (NCNT) are associated with biotinylated T cell stimuli and biotin-presenting PLG nanoparticles encapsulating IL-2 and magnetite. (b) Schematic of CNP functionality. CNPs present high density surface-adsorbed T cell stimuli, facilitate paracrine IL-2 release, and can be separated from T cells using magnetic separation. (c) Flow cytometry plots showing enhanced expansion of human EBV-specific CD8+ human T cells using CNPs presenting EBV peptide in MHC or anti-CD3 (OKT-3), compared to primary DCs loaded with EBV peptide and cultured in soluble IL-2. From [144].