Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Dec 1;6:344. doi: 10.3389/fgene.2015.00344

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Yang, Wagner and Beli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Protein–protein interactions are defined by temporal and spatial constraints. Many protein interactions are transient and occur only at specific time points, for instance in a particular cell cycle stage. These transient interactions can be mediated by posttranslational modification or by dynamic changes in expression of the binding partners. In addition to temporal constrains, protein interactions are spatially restricted by cellular compartments.