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. 2015 Dec 1;5:17576. doi: 10.1038/srep17576

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(A) mRNA expression of the five lysyl oxidase family members in murine tumor cells cultivated at 20% or 2% oxygen levels (n = 3). (B) Lysyl oxidase activity in the supernatant of murine tumor cells cultivated at 20% or 2% oxygen levels (n = 4). (C) Extravasation of Hoechst 33342 (blue) from vessels (Isolectin GS-B4, red) in implanted tumors. (D) Correlation between Hoechst 33342 penetration in tumors and DOX diffusion in tumor spheroids generated from different murine cell lines. Error bars: ±SEM. Scale bars: 100 μm. *indicate statistical significance versus respective controls, *P < 0.05, **P < 0.01, ***P < 0.001 and mRNA levels changed at least 2-fold.