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. 2015 Dec 1;5:17576. doi: 10.1038/srep17576

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(A) Relative lysyl oxidase activity in the supernatant of transfected and selected 4T1 cells (n = 4). (B) Time course of doxorubicin diffusion in tumor spheroids generated from 4T1 cells overexpressing hLOX versus control transfected cells. (C) Absolute diffusion rates into tumor spheroids generated from 4T1 cells overexpressing hLOX. (D) Time course of doxorubicin diffusion in tumor spheroids generated from 4T1 cells overexpressing hLOXL2 versus control transfected cells. (E) Absolute diffusion rates into tumor spheroids generated from 4T1 cells overexpressing hLOX. Tumor spheroids cultivated at 20% oxygen (n = 12). All images acquired on a laser scanning confocal microscope, Scale bars: 100 μm, Error bars: ±SEM.