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. 2015 Dec 1;5:17576. doi: 10.1038/srep17576

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(A) Experimental setup of drug exposure times and cultivation conditions. (B) EC₅₀ values for PTX and DOX after exposure of cells cultivated in 2D and exposure to the drugs for 72 h. (C) EC₅₀ values for PTX and DOX after exposure of cells cultivated in 2D and exposure to the drugs for 30 min. (D) EC₅₀ values for PTX and DOX after exposure of cells cultivated in 3D embedded in collagen I and exposure to the drugs for 30 min. (E) EC₅₀ values for 4T1 cells overexpressing hLOX or hLOXL2 cultivated in 2D and 3D culture and exposure to DOX for 30 min. Error bars: ±SEM, n = 4.