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Comparison of IHC vs. mRNA ISH for detecting TTF-1 expression in non-small cell lung cancer.
| mRNA ISH | ||||
|---|---|---|---|---|
| IHC | − | + | ++ | Total |
| − | 109 | 5 | 3 | 117 |
| + | 2 | 27 | 4 | 33 |
| ++ | 0 | 3 | 43 | 46 |
| Total | 111 | 35 | 50 | 196 |
Overall agreement, 0.913; κ-coefficient, 0.848. −, Absent staining; +, ≥30% of tumor cells with weak staining intensity; ++, ≥30% of tumor cells with strong staining intensity. TTF-1, thyroid transcription factor-1; IHC, immunohistochemistry; ISH, in situ hybridization.
