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. 2015 Oct 9;10(6):3769–3778. doi: 10.3892/ol.2015.3790

Figure 3.

Figure 3.

Effect of MTX on osteosarcoma cell apoptosis. Osteosarcoma cells (MG63 and U-2 OS) were infected with miR-126-overexpressing or -silencing lentiviral vectors. The effect of MTX on osteosarcoma cell apoptosis was then observed by flow cytometry. ΔΔ,※※P<0.01 vs. control group; ▲P<0.05 vs. pre-miR-126 group. DDP, cisplatin; MTX, methotrexate; RAPA, rapamycin; pre-miR-126, osteosarcoma cells infected with miR-126-overexpressing lentiviral vectors; anti-miR-126, osteosarcoma cells infected with miR-126-silencing lentiviral vectors.