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. 2015 Oct 9;10(6):3769–3778. doi: 10.3892/ol.2015.3790

Figure 6.

Figure 6.

Effect of MTX on the cell cycle of osteosarcoma cells. Osteosarcoma cells (MG63 and U-2-OS) were infected with miR-126-overexpressing or -silencing lentiviral vectors. The effect of MTX on the cell cycle of the osteosarcoma cells was then observed by flow cytometry. Blank control, untreated MG63 and U-2-OS. DDP, cisplatin; MTX, methotrexate; RAPA, rapamycin; pre-miR-126, osteosarcoma cells infected with miR-126-overexpressing lentiviral vectors; anti-miR-126, osteosarcoma cells infected with miR-126-silencing lentiviral vectors. ▲▲P<0.01, ▲P<0.05, v.s. untreated control group; ΔΔP<0.01, ΔP<0.05 v.s. pre-126 group; #P<0.05 v.s. MTX group; ※P<0.05 v.s. anti-126 group.