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MTSC22- and SC22EK-induced mutations in the NHR and CHR sites of HIV-1NL4-3 gp41. The amino acid sequences of wild-type (WT) and selected mutants are aligned. The positions of selected mutations are in bold, and numbering is according to that of HIV-1HXB2 gp41. The pocket-forming sequence in NHR and the pocket-binding domain in CHR with the M-T hook residues are underlined.
