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. 2015 Aug 28;10(5):2691–2698. doi: 10.3892/ol.2015.3654

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Forced expression of miRNA-34a-5p inhibits proliferation and promotes cell apoptosis. (A) Relative changes in the numbers of 97L cells transfected with the NC or miRNA-34a-5p mimic (P<0.05). (B) Relative changes in the number of 97L cells transfected with the NC or miRNA-34a-5p inhibitor (P<0.05). (C and D) Flow cytometry was performed to detect the apoptosis ratio in 97L cells transfected with miRNA-34a-5p mimics or inhibitors, with or without pretreatment with cisplatin (P<0.05). (E and F) Western blot analysis was performed to detect the protein expression of cleaved caspase-3 in the 97L cells transfected with miRNA-34a-5p mimics or inhibitors, with or without pre-treatment with cisplatin (P<0.05). All experiments were performed in triplicate. *P<0.05 and **P<0.001. miRNA-34a-5p, microRNA-34a-5p; MiR-34a, microRNA-34a; NC m, negative control mimic; NC inh, NC inhibitor; MiR-34a m, MiR-34a mimic; MiR-34a inh, MiR-34a inhibitor; DDP, cisplatin.