Table II.
Distribution of the BRCA1 methylation status with different hormone and epidermal growth factor receptors.
| BRCA1 methylation, n (total) | BRCA1 non-methylation, n (total) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| First author, year | Population | ER negative | PR negative | HER2 negative | Triple-negative | ER negative | PR negative | HER2 negative | Triple-negative | (Refs.) |
| Ignatov, 2013 | European | NA | NA | NA | 43 (86) | NA | NA | NA | 22 (46) | (21) |
| Krasteva, 2012 | European | 11 (23) | 11 (23) | 14 (17) | NA | 48 (112) | 11 (23) | 37 (53) | NA | (22) |
| Xu, 2009 | European | 89 (372) | 135 (372) | NA | NA | 127 (320) | 135 (372) | NA | NA | (23) |
| Xu, 2013 | Asian | 109 (285) | 149 (282) | 220 (279) | 64 (282) | 295 (830) | 149 (282) | 654 (810) | 142 (817) | (24) |
| Hsu, 2013 | Asian | 30 (77) | 36 (77) | 55 (77) | 16 (77) | 21 (61) | 36 (78) | 91 (138) | 5 (61) | (25) |
| Sharma, 2009 | Asian | 22 (27) | 21 (27) | 18 (27) | 15 (27) | 35 (74) | 21 (27) | 60 (74) | 25 (74) | (26) |
| Chen, 2009 | Asian | 55 (138) | 80 (137) | 98 (135) | 31 (136) | 127 (383) | 80 (137) | 298 (378) | 64 (382) | (27) |
| Jing, 2008 | Asian | 21 (33) | 26 (33) | NA | NA | 127 (168) | 26 (33) | NA | NA | (28) |
Total refers to the total number of identified samples in BRCA1 methylation or non-methylation with the corresponding hormone receptor: ER, PR and HER2. Triple-negative, lacks expression of ER, PR and HER2 amplification. ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; BRCA1, breast cancer susceptibility gene 1.