Table III.

HRs and 95% CI for the association between BRCA1 methylation and OS or DFS.

Analysis	Population	Survival	Pooled HR (95% CI), P-value	Heterogeneity test P-value	Eggers test P-value	Beggs test P-value
Univariate	European	OS	1.206 (0.444–3.276), 0.713	0.120	0.797	0.602
		DFS	–	–	–	–
	Asian	OS	2.164 (1.212–3.863), 0.009	0.011	0.004	0.174
		DFS	1.795 (1.109–2.907)	0.009	0.236	0.117
	Overall	OS	1.758 (1.154–2.679), 0.009	0.017	<0.001	0.393
		DFS	1.284 (0.679–2.430), 0.442	<0.001	1.000	0.885
Multivariate	European	OS	2.107 (0.827–5.368), 0.118	0.061	0.830	0.602
		DFS	0.876 (0.059–12.953), 0.923	<0.001	–	0.317
	Asian	OS	2.177 (0.711–6.663), 0.173	0.120	0.256	0.117
		DFS	2.250 (0.911–5.562), 0.079	0.021	0.074	0.117
	Overall	OS	1.966 (1.124–3.438), 0.018	0.058	0.019	0.460
		DFS	1.635 (0.638–4.191), 0.306	<0.001	<0.001	0.064

HR, hazard ratio; CI, confidence interval; BRCA1, breast cancer susceptibility gene 1; OS, overall survival; DFS, disease-free survival.