Table 1.
Table showing the changes in the caudate-putamen (CP) of rat following injection of SV(Tat). More numerous Tat-positive cells and TUNEL-positive cells were seen one month after injection of SV(Tat) in the CP (p < 0.01: SV(Tat) vs. SV(BUGT)). Neuronal loss was observed (p < 0.01: SV(Tat) vs. SV(BUGT)). An increase in the level of MDA, suggesting of oxidative stress, was also detected (p < 0.01: SV(Tat) vs. SV(BUGT)). CPs injected with SV(BUGT), an unrelated vector, did not show any modifications.
| Days/Tat-Induced Abnormalities | Nb Tat-Positive Cells/Area | Nb TUNEL-Positive Cells/Area | Neuron Loss (% Compared to Contralateral Area) | MDA (μM) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SV(BUGT) | SV(Tat) | P | SV(BUGT) | SV(Tat) | P | SV(BUGT) | SV(Tat) | P | SV(BUGT) | SV(Tat) | P | |
| d7 | - | 39.4 ± 4.2 | <0.01 | 2.1 ± 1.8 | 42.7 ± 4.8 | <0.01 | 1.9 ± 0.1 | 26.7 ± 3.2 | <0.01 | NA | NA | - |
| d14 | - | 48.7 ± 3.8 | <0.01 | - | 47.2 ± 4.5 | <0.01 | - | 30.8 ± 2.9 | <0.01 | 0.4 ± 0.03 | 1.4 ± 0.1 | <0.01 |
| d28 | - | 28.5 ± 3.4 | <0.01 | - | 24.6 ± 3.1 | <0.01 | - | 34.3 ± 3.6 | <0.01 | NA | NA | - |