Table III.
Comparison of genotype frequencies of the CASP8 gene polymorphisms between oral squamous cell carcinoma patients and control subjects.
| SNP | Model/allele | Genotype | Case (%) n=505 | Control (%) n=507 | P-valuea | OR (95% CI)b | Pac | AOR (95% CI)d |
|---|---|---|---|---|---|---|---|---|
| Rs3834129 | Additive | ii | 328 (65.0) | 276 (54.4) | 1.00 (Ref) | |||
| id | 159 (31.5) | 197 (38.9) | 0.04 | 0.679 (0.522–0.884) | 0.014 | 0.447 (0.235–0.850) | ||
| dd | 18 (3.5) | 34 (6.7) | 0.006 | 0.445 (0.246–0.806) | 0.002 | 0.640 (0.482–0.851) | ||
| Dominant | ii | 328 (65.0) | 276 (54.4) | 1.00 (Ref) | ||||
| id/dd | 177 (35.0) | 231 (45.6) | 0.001 | 0.645 (0.501–0.830) | <0.001 | 0.613 (0.467–0.806) | ||
| Recessive | ii/id | 487 (96.5) | 473 (93.3) | |||||
| dd | 18 (3.5) | 34 (6.7) | 0.024 | 0.514 (0.286–0.923) | 0.048 | 0.528 (0.281–0.993) | ||
| Rs13016963 | Additive | GG | 162 (32.1) | 164 (32.3) | 1.00 (Ref) | |||
| AG | 243 (48.1) | 264 (52.1) | 0.619 | 0.932 (0.705–1.231) | 0.765 | 0.955 (0.706–1.291) | ||
| AA | 100 (19.8) | 79 (15.6) | 0.184 | 1.281 (0.888–1.848) | 0.156 | 1.332 (0.896–1.981) | ||
| Dominant | GG | 162 (32.1) | 164 (32.3) | 1.00 (Ref) | ||||
| AG/AA | 343 (67.9) | 343 (67.7) | 0.927 | 1.012 (0.778–1.318) | 0.787 | 1.040 (0.781–1.385) | ||
| Recessive | GG/AG | 405 (80.2) | 428 (84.4) | 1.00 (Ref) | ||||
| AA | 100 (19.8) | 79 (15.6) | 0.079 | 1.338 (0. 967–1.851) | 0.077 | 1.1371 (0.967–1.945) |
a
P-value and
b
OR with 95% CIs estimated by unconditional logistic regression.
c
P-value and
d
AOR with 95% CIs estimated by multiple logistic regression models after controlling age, gender, smoking and drinking. CASP8, caspase-8; SNP, single nucleotide polymorphism; ref, reference; OR, odds ratio; AOR, adjusted odds ratio; CI, confidence interval; ii, ins/ins; id, ins/del; dd, del/del.