Table IV.
Comparison of genotype frequencies of CASP8 gene polymorphisms in smokers and non-smokers.
| Smoking status | SNP | Model/allele | Genotype | Case, n (%) | Control, n (%) | P-valuea | OR (95% CI)b | Pac | AOR (95% CI)d |
|---|---|---|---|---|---|---|---|---|---|
| Smokere | rs3834129 | Additive | ii | 194 (63.8) | 87 (52.7) | 1.00 (Ref) | |||
| id | 100 (32.9) | 70 (42.4) | 0.027 | 0.641 (0.431–0.952) | 0.057 | 0.660 (0.430–1.013) | |||
| dd | 10 (3.3) | 8 (4.9) | 0.234 | 0.561 (0.214–1.469) | 0.076 | 0.395 (0.142–1.102) | |||
| Dominant | ii | 194 (63.8) | 87 (52.7) | 1.00 (Ref) | |||||
| id/dd | 110 (36.2) | 78 (47.3) | 0.019 | 0.632 (0.430–0.929) | 0.027 | 0.627 (0.415–0.949) | |||
| Recessive | ii/id | 294 (96.7) | 157 (95.1) | 1.00 (Ref) | |||||
| dd | 10 (3.3) | 8 (4.9) | 0.401 | 0.668 (0.258–1.725) | 0.132 | 0.459 (0.167–1.263) | |||
| rs13016963 | Additive | GG | 99 (32.6) | 54 (32.7) | 1.00 (Ref) | ||||
| AG | 150 (49.3) | 83 (50.3) | 0.947 | 0.986 (0.644–1.510) | 0.916 | 1.025 (0.646–1.627) | |||
| AA | 55 (18.1) | 28 (17.0) | 0.810 | 1.071 (0.610–1.881) | 0.897 | 1.041 (0.569–1.902) | |||
| Dominant | GG | 99 (32.6) | 54 (32.7) | 1.00 (Ref) | |||||
| AG/AA | 205 (67.4) | 111 (67.3) | 0.972 | 1.007 (0.673–1.509) | 0.897 | 1.029 (0.665–1.593) | |||
| Recessive | GG/AG | 249 (81.9) | 137 (83.0) | 1.00 (Ref) | |||||
| AA | 55 (18.1) | 28 (17.0) | 0.761 | 1.081 (0.655–1.783) | 0.928 | 1.025 (0.600–1.752) | |||
| Non-smokerf | rs3834129 | Additive | ii | 134 (66.7) | 189 (55.3) | 1.00 (Ref) | |||
| id | 59 (29.3) | 127 (37.1) | 0.029 | 0.655 (0.448–0.958) | 0.036 | 0.655 (0.440–0.973) | |||
| dd | 8 (4.0) | 26 (7.6) | 0.042 | 0.434 (0.191–0.988) | 0.032 | 0.395 (0.169–0.922) | |||
| Dominant | ii | 134 (66.7) | 189 (55.3) | 1.00 (Ref) | |||||
| id/dd | 67 (33.3) | 153 (44.7) | 0.009 | 0.618 (0.430–0.888) | 0.010 | 0.608 (0.417–0.887) | |||
| Recessive | ii/id | 193 (96) | 316 (92.4) | 1.00 (Ref) | |||||
| dd | 8 (4.0) | 26 (7.6) | 0.093 | 0.504 (0.224–1.135) | 0.069 | 0.460 (0.199–1.061) | |||
| rs13016963 | Additive | GG | 63 (31.3) | 110 (32.2) | 1.00 (Ref) | ||||
| AG | 93 (46.3) | 181 (52.9) | 0.593 | 0.897 (0.603–1.336) | 0.563 | 0.885 (0.584–1.340) | |||
| AA | 45 (22.4) | 51 (14.9) | 0.094 | 1.541 (0.928–2.557) | 0.034 | 1.785 (1.045–3.052) | |||
| Dominant | GG | 63 (31.3) | 110 (32.2) | 1.00 (Ref) | |||||
| AG/AA | 138 (68.7) | 232 (67.8) | 0.843 | 1.039 (0.714–1.510) | 0.758 | 1.063 (0.720–1.571) | |||
| Recessive | GG/AG | 156 (77.6) | 291 (85.1) | 1.00 (Ref) | |||||
| AA | 45 (22.4) | 51 (14.9) | 0.027 | 1.646 (1.054–2.570) | 0.007 | 1.924 (1.199–3.089) |
a
P-value and
b
OR with their 95% CIs were estimated using unconditional logistic regression.
c
P-value and
d
AOR with 95% CIs estimated using multiple logistic regression models after controlling age, gender and drinking.
e
Case, n=304; control, n=165.
f
Case, n=201; control, n=342. CASP, caspase-8; SNP, single nucleotide polymorphism; ref, reference; OR, odds ratio; AOR, adjusted odds ratio; CI, confidence interval; ii, ins/ins; id, ins/del; dd, del/del.