Table VI.
Comparison of genotype frequencies of CASP8 gene polymorphisms in men and women.
| Gender | SNP | Model/allele | Genotype | Case, n (%) | Control, n (%) | P-valuea | OR (95% CI)b | Pac | AOR (95% CI)d |
|---|---|---|---|---|---|---|---|---|---|
| Malee | rs3834129 | Additive | ii | 212 (64.2) | 195 (56.0) | 1.00 (Ref) | |||
| id | 109 (33.0) | 133 (38.2) | 0.082 | 0.754 (0.548–1.037) | 0.056 | 0.409 (0.164–1.022) | |||
| dd | 9 (2.8) | 20 (5.8) | 0.028 | 0.414 (0.184–0.931) | 0.044 | 0.687 (0.477–0.989) | |||
| Dominant | ii | 212 (64.2) | 195 (56.0) | 1.00 (Ref) | |||||
| id/dd | 118 (35.8) | 153 (44) | 0.029 | 0.709 (0.521–0.966) | 0.017 | 0.652 (0.458–0.928) | |||
| Recessive | ii/id | 321 (97.2) | 328 (94.2) | 1.00 (Ref) | |||||
| dd | 9 (2.8) | 20 (5.8) | 0.052 | 0.460 (0.206–1.025) | 0.100 | 0.467 (0.189–1.155) | |||
| rs13016963 | Additive | GG | 101 (30.6) | 120 (34.5) | 1.00 (Ref) | ||||
| AG | 166 (50.3) | 176 (50.6) | 0.510 | 1.121 (0.798–1.573) | 0.651 | 1.094 (0.742–1.611) | |||
| AA | 63 (19.1) | 52 (14.9) | 0.114 | 1.439 (0.915–2.264) | 0.262 | 1.342 (0.803–2.241) | |||
| Dominant | GG | 101 (30.6) | 120 (34.5) | 1.00 (Ref) | |||||
| AG/AA | 229 (69.4) | 228 (65.5) | 0.282 | 1.193 (0.865–1.647) | 0.453 | 1.152 (0.797–1.665) | |||
| Recessive | GG/AG | 267 (80.9) | 296 (85.1) | 1.00 (Ref) | |||||
| AA | 63 (19.1) | 52 (14.9) | 0.150 | 1.343 (0.898–2.009) | 0.303 | 1.269 (0.806–1.997) | |||
| Femalef | rs3834129 | Additive | ii | 116 (66.3) | 81 (50.9) | 1.00 (Ref) | |||
| id | 50 (28.6) | 64 (40.3) | 0.010 | 0.546 (0.342–0.870) | 0.034 | 0.582 (0.352–0.961) | |||
| dd | 9 (5.1) | 14 (8.8) | 0.070 | 0.449 (0.185–1.087) | 0.064 | 0.408 (0.158–1.054) | |||
| Dominant | ii | 116 (66.3) | 81 (50.9) | 1.00 (Ref) | |||||
| id/dd | 59 (33.7) | 78 (49.1) | 0.004 | 0.528 (0.340–0.821) | 0.013 | 0.549 (0.341–0.883) | |||
| Recessive | ii/id | 166 (94.9) | 145 (91.2) | 1.00 (Ref) | |||||
| dd | 9 (5.1) | 14 (8.8) | 0.187 | 0.562 (0.236–1.336) | 0.171 | 0.527 (0.210–1.320) | |||
| Rs13016963 | Additive | GG | 61 (34.9) | 44 (27.7) | 1.00 (Ref) | ||||
| AG | 77 (44.0) | 88 (55.3) | 0.067 | 0.631 (0.385–1.034) | 0.082 | 0.619 (0.360–1.062) | |||
| AA | 37 (21.1) | 27 (17.0) | 0.971 | 0.988 (0.527–1.855) | 0.980 | 0.991 (0.503–1.955) | |||
| Dominant | GG | 61 (34.9) | 44 (27.7) | 1.00 (Ref) | |||||
| AG/AA | 114 (65.1) | 115 (72.3) | 0.158 | 0.715 (0.449–1.140) | 0.182 | 0.706 (0.423–1.178) | |||
| Recessive | GG/AG | 138 (78.9) | 132 (83.0) | 1.00 (Ref) | |||||
| AA | 37 (21.1) | 27 (17.0) | 0.334 | 1.311 (0.756–2.273) | 0.317 | 1.346 (0.752–2.411) |
a
P-value and
b
OR with 95% CIs estimated by unconditional logistic regression.
c
P-value and
d
AOR with 95% CIs estimated by multiple logistic regression models after controlling age, smoking and drinking.
e
Case, n=330; control, n=348.
f
Case, n=175; control, n=159. CASP, caspase-8; SNP, single-nucleotide polymorphism; Ref, reference; OR, odds ratio; AOR, adjusted odds ratio; CI, confidence interval; ii, ins/ins; id, ins/del; dd, del/del.