Table 1.

Differentially expressed miRNAs in liver tissues and hepatocellular carcinoma (HCC) cell lines.

Sample type	Method	miRNAs *	Cellular Target/Mechanism	Reference
Tumor tissues	Microarray, qPCR	miR-199a, miR-92, miR-106a, miR-222, miR-17-5p, miR-18, miR-20	Tumor progression	[23]
Tumor tissues, rat model of hepatoma	Microarray, Northern blot	miR-122, let-7a, miR-21, miR-23, miR-130, miR-190, miR-17-92 family	Tumorigenesis	[30]
Tumor tissue	Microarray	miR-122	Loss of mitochondrial metabolism	[31]
HCC cell lines	qPCR	miR-122	NDRG3	[32]
Tumor tissues, HCC cell lines	Microarray, qPCR Northern blot	miR-122 let-7 family, miR-145	Cyclin G1	[33]
HCC cell lines	Western blot, Soft agar assay	miR-122	ADAM17, migration, invasion, anchorage-dependence, angiogenesis, metastasis	[34]
Tumor tissues, HCC cell lines	qPCR, Western blot	miR-34a	c-Met, apoptosis, cell cycle arrest, Senescence	[36]
Tumor tissues, HCC cell lines	Microarray, Northern blot, Western blot	miR-101	Mcl-1, apoptosis, tumor suppression	[39]
Tumor tissues	Microarray, qPCR	miR-199-a-5p, miR-223	Cell cycle inhibition	[22,35,36,37,38,40]
Human and Woodchuck HCC cell lines	qPCR, Northern blot	miR-17-92, miR-21	Cell proliferation, apoptosis	[41]
Tumor tissues	qPCR, Northern blot	miR-221	CDKN1C/p57, CDKN1B/p27	[42]
Tumor tissues	Microarray, qPCR, Northern blot	miR-21	PTEN	[43]
Tumor tissues	Microarray	miR-224	Apoptosis inhibitor-5	[44]

* Downregulated miRNAs were shown in italics.