Table 2.
Standardized regression coefficients (β) and R2 from hierarchical regression models for individual FTO SNPs predicting total energy intake, carbohydrate intake, fat intake, protein intake and sugar intake.a
rs9936768 52457064 |
rs8049933 52651631 |
rs7199716 52590749 |
rs12921970 52422727 |
rs12446047 52554803 |
rs11076022 52708479 |
|
---|---|---|---|---|---|---|
Total Energy Intake (kcal) | ||||||
RRVfoodb | 0.371* | 0.371* | 0.371* | 0.371* | 0.371* | 0.371* |
SNP | −0.111 | 0.024 | 0.129 | 0.096 | −0.039 | 0.063 |
RRVfood x SNP | −0.323** | −0.295** | 0.318** | 0.294** | 0.344** | 0.306** |
Total R2 | 0.206 | 0.191 | 0.216 | 0.205 | 0.211 | 0.203 |
Carbohydrate Intake (kcal) | ||||||
RRVfood | 0.367* | 0.367* | 0.367* | 0.367* | 0.367* | 0.367* |
SNP | −0.109 | 0.018 | 0.127 | 0.098 | −0.032 | 0.062 |
RRVfood x SNP | −0.311** | −0.284** | 0.312** | 0.295** | 0.335** | 0.297** |
Total R2 | 0.201 | 0.186 | 0.213 | 0.205 | 0.206 | 0.199 |
Fat Intake (kcal) | ||||||
RRVfood | 0.375* | 0.375* | 0.375* | 0.375* | 0.375* | 0.375* |
SNP | −0.114 | 0.029 | 0.132 | 0.094 | −0.038 | 0.064 |
RRVfood x SNP | −0.332** | −0.305** | 0.318** | 0.293** | 0.349** | 0.311** |
Total R2 | 0.208 | 0.193 | 0.216 | 0.204 | 0.212 | 0.203 |
Protein Intake (kcal) | ||||||
RRVfood | 0.289* | 0.289* | 0.289* | 0.289* | 0.289* | 0.289* |
SNP | −0.117 | 0.012 | 0.133 | 0.122 | −0.052 | 0.033 |
RRVfood x SNP | −0.228 | −0.231 | 0.294** | 0.303** | 0.287** | 0.223 |
Total R2 | 0.172 | 0.164 | 0.203 | 0.206 | 0.183 | 0.165 |
Sugar Intake (kcal) | ||||||
RRVfood | 0.364* | 0.364* | 0.364* | 0.364* | 0.364* | 0.364* |
SNP | −0.114 | −0.012 | 0.133 | 0.105 | −0.060 | 0.090 |
RRVfood x SNP | −0.253 | −0.246 | 0.216 | 0.276** | 0.264** | 0.270** |
Total R2 | 0.199 | 0.189 | 0.202 | 0.214 | 0.199 | 0.207 |
p < 0.001
p < 0.000735 (corrected using false discovery estimates for the 68 FTO SNPs studied) using PLINK.
Controlled for proportion African, the highest reinforcement schedule of reading and BMI.
RRVfood = the highest reinforcement schedule completed for access to food or alternatives in the RRV task.