Figure 2.
Expression of SUSD2 protein in normal lung and NSCLC tissues by immunohistochemical analysis of the tissue microarray. (A) Positive expression of SUSD2 in normal lung tissue, in which ~90% of the lung cells demonstrated marked membrane staining of SUSD2, while lesser staining was also observed in the cytoplasm (magnification, ×100). (B) Positive expression of SUSD2 in NSCLC (case 13), in which >90% of tumor cells exhibited positive staining (magnification, ×100). (C) Negative expression of SUSD2 in NSCLC (case 168), with <35% positive tumor cells (magnification, ×100). (D) Negative expression of SUSD2 in NSCLC (case 74), with <20% positive tumor cells (magnification, ×100). (E) Negative expression of SUSD2 in NSCLC (case 161), with <5% positive tumor cells (magnification, ×100). (F-J) Higher magnification (×400) of the black squares outlined in A-E, respectively. SUSD2, sushi domain containing 2; NSCLC, non-small cell lung cancer.