Table III.
Effects of FBRA on the incidence and distribution of pathological lesions in the pancreas.
| Incidence of highest-grade lesions in affected animals, n (%) | ||||||
|---|---|---|---|---|---|---|
| Group | Treatment (no. of animals examined) | Animals with no lesions, n (%) | PanIN1 | PanIN2 | PanIN3 | Invasive ca. |
| 1 | BOP (34) | 1 (3) | 4 (12) | 10 (29) | 11 (32) | 8 (24) |
| 2 | BOP+5% FBRA (30) | 2 (7) | 3 (10) | 13 (43) | 5 (17) | 7 (23) |
| 3 | BOP+10% FBRA (29) | 1 (4) | 9 (31) | 11 (38) | 3 (10) | 5 (17) |
| 4 | BOP→5% FBRA (30) | 0 (0) | 2 (7) | 13 (43) | 7 (23) | 8 (27) |
| 5 | BOP→10% FBRA (29) | 3 (10) | 12 (42) | 7 (24) | 3 (10) | 4 (14) |
| 6 | 10% FBRA (10) | 10 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| 7 | Control diet (10) | 10 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
Kruskal-Wallis test with Dunn's post-hoc test showed significant differences between groups 1 and 5 (P<0.05). PanIN, pancreatic intraepithelial neoplasia; ca., adenocarcinoma; BOP, N-nitrosobis(2-oxopropyl)amine; FBRA, fermented brown rice by Aspergillus oryzae.