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. 2015 Aug 27;10(5):3095–3102. doi: 10.3892/ol.2015.3649

Figure 3.

Figure 3.

HBsAg and HBeAg secretion and HBV DNA replication were inhibited by transfection with pS-miR-34c, as shown by ELISA assay. (A) Transfection with pS-miR-34c had a significant inhibitory effect on HBsAg levels compared with pS-control-transfected and untreated cells, and the inhibitory ratio was 24.39% (***P<0.001). (B) Transfection with pS-miR-34c inhibited the expression of HBeAg, and the inhibitory ratio was 48.67% (***P<0.001). (C) DNA copy number of HBV in cells transfected with pS-miR-34c was reduced by 83.27% 48 h after transfection compared with untreated cells and cells transfected with the pS-control vector (***P<0.001). All data were obtained from three independent experiments. miR-34c, microRNA-34c; HBV, hepatitis B virus; pS, plasmid; HBsAg, hepatitis B virus surface antigen; HBeAg, hepatitis B virus e antigen.